Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway.
| Author | |
|---|---|
| Abstract |
:
Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN) protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy. Angiotensin II (Ang II) plays a critical role in the development of diabetic cardiomyopathy. Therefore, whether SFN prevents Ang II-induced cardiomyopathy through activation of Nrf2 was examined using wild-type, global deletion of Nrf2 gene (Nrf2-KO) and cardiomyocyte-specific overexpression of Nrf2 gene (Nrf2-TG) mice. |
| Year of Publication |
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2018
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| Journal |
:
Redox biology
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| Volume |
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15
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| Number of Pages |
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405-417
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| Date Published |
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2018
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| URL |
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http://linkinghub.elsevier.com/retrieve/pii/S2213-2317(17)30864-9
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| DOI |
:
10.1016/j.redox.2017.12.016
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| Short Title |
:
Redox Biol
|
| Download citation |
