Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma.
| Author | |
|---|---|
| Abstract |
:
The TNFAIP3 gene, which encodes a ubiquitin-modifying enzyme (A20) involved in the negative regulation of NF-κB signaling, is frequently inactivated by gene deletions/mutations in a variety of B-cell malignancies. However, the detection of this in primary Hodgkin lymphoma (HL) specimens is hampered by the scarcity of Hodgkin Reed-Sternberg (HR-S) cells even after enrichment by micro-dissection. |
| Year of Publication |
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2012
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| Journal |
:
BMC cancer
|
| Volume |
:
12
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| Number of Pages |
:
457
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| Date Published |
:
2012
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| URL |
:
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-457
|
| DOI |
:
10.1186/1471-2407-12-457
|
| Short Title |
:
BMC Cancer
|
| Download citation |
