A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis.
| Author | |
|---|---|
| Abstract |
:
Genetic variants in the chromosomal region 17q21 are consistently associated with asthma. However, mechanistic studies have not yet linked any of the associated variants to a function that could influence asthma, and as a result, the identity of the asthma gene(s) remains elusive. |
| Year of Publication |
:
2018
|
| Journal |
:
The Journal of allergy and clinical immunology
|
| Date Published |
:
2018
|
| ISSN Number |
:
0091-6749
|
| URL |
:
http://linkinghub.elsevier.com/retrieve/pii/S0091-6749(18)30023-X
|
| DOI |
:
10.1016/j.jaci.2017.11.040
|
| Short Title |
:
J Allergy Clin Immunol
|
| Download citation |
