Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells.
| Author | |
|---|---|
| Abstract |
:
Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal stem cells (BM-MSCs) represent as an ideal biological source for cell therapy. The aim of this study was to identify whether targeting the promotor of ectodysplasin (EDA) by CRISPR/dCas9-effector (dCas9-E) could induce the BM-MSCs to differentiate into sweat gland-like cells (SGCs). |
| Year of Publication |
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2018
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| Journal |
:
Stem cell research & therapy
|
| Volume |
:
9
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| Issue |
:
1
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| Number of Pages |
:
8
|
| Date Published |
:
2018
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| URL |
:
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0758-0
|
| DOI |
:
10.1186/s13287-017-0758-0
|
| Short Title |
:
Stem Cell Res Ther
|
| Download citation |
