Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency.
| Author | |
|---|---|
| Abstract |
:
Treatment of tumors with macromolecular toxins directed to cytoplasmic targets requires selective endocytosis followed by release of intact toxin from the endosomal/lysosomal compartment. The latter step remains a particular challenge. Claudins 3 and 4 are tight junction proteins that are over-expressed in many types of tumors. This study utilized the C-terminal 30 amino acid fragment of C. perfringens enterotoxin (CPE), which binds to claudins 3 and 4, to deliver a toxin in the form of recombinant gelonin (rGel) to the cytoplasm of the human ovarian carcinoma cell line 2008. |
| Year of Publication |
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1969
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| Journal |
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BMC cancer
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| Volume |
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11
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| Number of Pages |
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61
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| Date Published |
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2011 Feb 8
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| URL |
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http://www.biomedcentral.com/1471-2407/11/61
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| DOI |
:
10.1186/1471-2407-11-61
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| Short Title |
:
Challenges associated with the targeted delivery of gelonin to c
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| Download citation |
